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Because of its wide availability paired with comparably high toxicity, (compared to ibuprofen and aspirin) there is a much higher potential for overdose.
Ideally, mAbs selectively target tumour cells, resulting in limited toxicity compared to classical chemotherapy.
It has been shown that Cu-doped TiO2 induces more toxicity compared to TiO2 [19].
Pembrolizumab and nivolumab have higher response rates and less toxicity compared to ipilimumab.
All synthesized vectors showed significantly lower cellular toxicity compared to bare polymer.
Carbon-based emitters are chemically inert resulting in low toxicity compared to other inorganic colloidal nanoscale light emitters [2].
However, a number of approaches to designing NPs with a decreased toxicity compared to the traditional NPs are already available.
Among these results, we found that SWCNTs had a greater toxicity compared to the other two nanomaterials.
Uncoated superparamagnetic NPs induced greater toxicity compared to that of NPs after coating with biocompatible polyvinyl alcohol (PVA) [13].
In vivo, liposomal carfilzomib demonstrated significant tumor growth inhibition and dramatically reduced overall systemic toxicity compared to free carfilzomib.
Saline-pretreated mixed responders (n=6) had greater tolerance to cocaine toxicity compared to vascular responders (n=11).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com