Exact(3)
The patients were evaluated for toxicity at day 42 (end of radiotherapy) and dysphagia/oesophagitis was recorded according to CTC Commonn Toxicity Criteria's version 2.0).
We then determined whether Nrf2 activation by multiple doses of oltipraz administration rescued the kidney from cisplatin toxicity at day 5 (at which serum creatinine level sufficiently increased).
The patient with a DLT at the dose level of 1000 mg m−2 developedeloped grade 3 urological toxicity at day 12 of treatment, which resolved slowly after discontinuation of all treatment.
Similar(57)
Therefore, viral gene expression is a primary determinant of intermediate and chronic toxicities at day 3 and week 4 post-injection.
For all surviving animals, the clinical chemistry and hematology indicators of toxicity observed at day 5 were essentially resolved by day 12 (SI Figure S3).
All toxicity was graded according to the National Cancer Institute Common Toxicity Criteria and toxicity assessments performed at day 1 of every cycle until the end of treatment.
If indicated, a second dose adjustment based on TTL and/or toxicity was performed at day 36, as described before.
If either count was below these levels, treatment was delayed for 1 week and in case of nonrecovery or nonhaematological toxicity ⩾grade 2 at day 21, the dose of docetaxel given at the next cycle was reduced by 25%.
Toxicities were evaluated at day 1 of each cycle according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale, version 3.0.
Routine monitoring of ART for hepatic and haematological toxicity at the 15th day of ART is common practice.
If toxicity grade >1 persisted at day 21, treatment was delayed for up to 2 weeks.
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