Sentence examples for toxic stimulus from inspiring English sources

Interestingly, in differentiated neuronal cultures, PrPC and Sho exert similar protective effects against a toxic stimulus [11].

Our data indicate that motor neuron death in ALS cannot be prevented by inhibition of a single inflammatory pathway because alternative pathways are activated in the presence of a persistent toxic stimulus.

Aβ is known to be a toxic stimulus in a variety of model systems, and emerging experimental and clinical attempts to intervene in the disease process have shown preliminary success by preventing the production or enhancing clearance of the Aβ peptide [3], [4], [5], [6].

This is consistent with the majority of studies describing a protective role of NPY, where the peptide was applied before the toxic stimulus.

This suggests that rotenone-induced toxicity is mediated by concomitant disruption of counteractive mechanisms such as SK channels that disappear after the toxic stimulus.

In contrast to mature tissues or cells, model systems of development do not have a stable baseline, i.e., the transcriptome changes over time, also without toxic stimulus.

I visited Dr. A. J. Emami, a well-recommended ear, nose and throat specialist in Tucson, who explained that the olfactory nerve is the first of the 12 cranial nerves, and that the fifth one responds to toxic stimuli.

Candidate neuroprotective agents include those that interact specifically with neuronal targets to inhibit deleterious intraneuronal mechanisms triggered by Aβ and other toxic stimuli.

It is known that JNK participates in the apoptotic signaling pathway initiated by stress or toxic stimuli [44].

However, cultured neuronal cells derived from AID transgenic mice were more sensitive to selective apoptotic and toxic stimuli.

We used three different HD relevant toxic stimuli: MG132 (a reversible proteasome inhibitor), 3-NP (a mitochondrial toxin) or QA (quinolinic acid, an excitotoxin).