What's particularly toxic about this scenario is that unlike Otter, Larry is one of the good guys.
Inherited, disease-causing myocilin variants aggregate intracellularly instead of being secreted to the trabecular meshwork, which is a scenario toxic to trabecular meshwork cells and leads to early onset of ocular hypertension, the major risk factor for glaucoma.
For many potential deliberate release scenarios using toxic chemicals, the quantity of chemical required to successfully execute the scenario is modest, ranging from grams to 100 kilograms, especially if the release is in a confined space.
In aquatic environments, many factors determine the overall impact of a toxic event, constituting "exposure scenarios" that must be understood so that risk assessment strategies can be successfully applied.
But a relationship with a douche is a scenario far more toxic than the expected drama of normal coupling.
The issues at play in this repugnant scenario include a toxic stew of over-zealous police work, poorly trained officers, a culture within law enforcement of racial prejudice and animus, and a predisposition in the black community -- engendered and fomented by years of the above -- to distrust, disdain and outright fear police.
Thus, the present scenario and the toxic side effects associated with the available treatments calls for alternative methods, with higher efficacy and lesser noxious side effects, to deal with this disease.
In this scenario m8 would be toxic because it produces more of the same toxic species than wt, and thus leads to a strong mortality.
If CQ toxicity results from the latter scenario, then inhibiting autophagosome formation should inhibit CQ toxicity by reducing toxic intermediates.
These trends are more evident for case B scenarios, where the toxic flow rates are much lower.
