Paint exposures appeared to be specifically related to ALL with t(12 21), but we are not sure whether they influence the identified genetic "hits" or influence the progression of the disease via other means, for instance, epigenetic changes or nongeno-toxic bone marrow suppression followed by regrowth (Wiemels et al. 2008).
Finally, the result of biological property testing proved that HA-TiO2 film had a bio-compatible property and UV light affect the TiO2 composition to be a toxic with bone cell.
Although benzene is known to be specifically toxic to bone marrow in humans, the mechanism for this is not understood (Whysner et al. 2004).
Pb is locally toxic to bone, and intraarticular Pb, as demonstrated with retained Pb bullets, can lead to arthritis, synovitis and even systemic toxicity [ 43, 44].
The literature on cadmium exposure and osteoporosis suggests that cadmium may be directly toxic to bone in adults, leading to increased risk of osteoporosis (46– 46).
Molybdenum in the human body accumulates in the liver, kidneys, bones, and teeth [ 20] An excess of Mo is toxic and causes bone deformities similar to the changes occurring in the rheumatoid arthritis, tooth decay, and disorders of lipid and protein [ 4].
These advocates point to mistakes like toxic chemotherapy with bone marrow transplants in breast cancer, which in the 1980s and 1990s increased the suffering of nearly 30,000 women before studies finally showed that it was ineffective.
Furthermore, compound 5c was not toxic to murine bone marrow cell growth in culture, at a dose that was toxic for the previously reported seco-CBI (cyclopropylbenzoindoline -TMI (4).
Haematopoietic colony-stimulating factors are used frequently to moderate myelotoxicity, but administration of granulocyte-colony-stimulating factor (G-CSF) prior to chemotherapy actually may worsen the toxic effects on bone marrow.
