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Besides hepatic toxicity, no AAP toxic actions have been described in the nervous system, although it is well known that AAP crosses the blood-brain barrier both in rodents and humans [6].
Several congeners of these pollutants exhibit various biological and toxic actions, such as dermal toxicity, immunotoxicity, carcinogenicity, and adverse effects on reproductive, neuro behavioral, and endocrine functions (Lindström et al. 1995; Weisglas-Kuperus 1998).
Third, gene expression studies are now powerful enough to discriminate and classify toxicants on the basis of unique gene expression profiles induced by putative toxic actions.
ACN is known to exert toxic actions to human beings as well as experimental animals.
Cocaine mediates its reinforcing and toxic actions through a "loss of function" effect at multiple receptors.
Nevertheless, in most cases, hemodynamic or toxic actions seem to be insufficient in the pathogenesis of AKI [89].
Carbon tetrachloride (CCl4) is a widely used solvent in chemical industries and well known for its hepatic and renal toxic actions.
Metals constitute a particular risk to human health because they can accumulate in vital organs of man (Nurnberg 1982) and exert progressively growing toxic actions over long periods of exposure (Akoto et al. 2008).
The current perspective discusses chemical transformations of Cr III) nutritional supplements in biological media, with implications for both beneficial and toxic actions of Cr III) complexes, which are likely to arise from the same biochemical mechanisms, dependent on concentrations of the highly reactive Cr (IV/V/VI) species, formed in the reactions of Cr III) with biological oxidants [10].
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Treatment options and drugs with potential mitochondrion-toxic actions (i.e., valproic acid, metformin, linezolid, etc).
These paradoxical effects in experimental and animal studies of the metal, i.e. both trophic osseous actions and bone-toxic actions, are enigmatic and await further explanation.
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