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Undoubtedly, it is beneficial to have increased catalase activity during stress conditions [31], since a whole range of stress conditions are known to cause toxic accumulations of H2O2 [32].
These cells can migrate to the brain and clear the toxic accumulations of the enzyme substrate 26.
The NR1I family of orphan nuclear receptors are known to prevent toxic accumulations of xenobiotics within cells by regulating a broad range of cellular transporters [ 17, 30, 31].
S. cerevisiae responds by up regulating transporter proteins, such as Pma1 and Pdr12, which secrete protons and carboxylate anions, respectively, to avoid toxic accumulations.
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Toxic accumulation is one of the reasons repetitive exposures of a chemical produce toxicity while a single exposure may not.
PKU, an autosomal recessive metabolic disorder, causes a toxic accumulation of dietary phenylalanine in the brain.
Nine human disorders result from the toxic accumulation and aggregation of proteins with expansions in their endogenous polyalanine (polyA) tracts.
Such toxic accumulation of waste materials in cells prevents normal functions and can lead to early death, as does Tay-Sachs.
It is a toxic accumulation of dietary copper in the liver, brain and other organs, leading to progressive neurological and behavioral problems and, if untreated, death.
A defect in any of the enzymes of the urea cycle leads to a toxic accumulation of ammonia in the blood.
First described in 1912 by Dr. Samuel A. K. Wilson, the disease is caused by a toxic accumulation of dietary copper in the liver, brain and other organs, leading to progressive neurological and behavioral problems and, if untreated, death.
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