Suggestions(2)
Exact(4)
Since the flow of (1.6) moves toward down on the line where and and moves towards up on the line where and, it is easy to see that any potential limit cycle of (1.6) must lie in the region where.
In addition, no clear trend towards up- or downregulation of the pathway is visible (Additional file 8).
Kidney tumors showed the opposite expression pattern, with Msi1 and Msi2 downregulated in a majority of tumors and rarely upregulated, and in thyroid cancer neither Msi1 nor Msi2 showed a strong bias towards up- or down-regulation.
Alternative approaches must be developed for microarrays where the proportion of modulated genes and their distribution are unknown and they may be biased towards up- or down-modulated trends.
Similar(56)
However, these bio-electrocatalyzed systems pose significant challenges towards up-scaling and practical applications.
Generally, a tendency towards up-scalable and automatizable processes is observed.
There are numerous technical issues ahead for MEC to be tackled towards up-scaling and real implementations.
However, this technology is still in its infancy period and poses various challenges towards up-scaling and widespread applications, such as such as lower hydrogen production rate (HPR), high internal resistance, complicated architecture, and expensive materials.
A second miRNA identified in this study, miR-26a, exhibited a trend towards up-regulation in our study (>1.3 fold up-regulated in 5 out of 6 mice).
In contrast chronically-treated Mutyh−/− mice show a trend towards up-regulation of IFNγ, IL12a and IL-6 suggesting that the chronic inflammation occurring in these mice is characterized by the persistence of cytokines dominating the acute phase.
None of these genes showed a statistically significant change in Mutyh−/− mice, although a trend towards up-regulation of IFNγ, IL-12a, IL-6 was observed (data not shown).
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