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The entropy reduction of α-helix IX is thought to inhibit its functionally important structural flexibility, while the deeper energy barrier shifted the population of active antiporters towards inhibited antiporters.
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Contrary to Au-LPa small, Au-LPa large inhibited S. mutans to great extent even at lower concentrations but showed dose dependent response towards inhibiting S. aureus biofilms (54 84% inhibition at 0.003125 0.025 mM).
Mutational studies directed towards inhibiting chromophore formation indicate that the novel backbone cyclization is responsible for the hysteresis observed in equilibrium titrations of sfGFP.
Supplementation with exogenous fetuin-A could tilt the balance towards inhibiting active HMGB1 release (Fig. 6).
Recently developed biological agents are directed towards inhibiting TNFα signaling.
In this respect, controlling the pattern of 5-FU activation, preferentially towards inhibiting TS FdUMP synthesis, is a major goal for optimising its anticancer efficacy.
The expression of Beclin-1 and Bax in HCC tissues may provide a synergistic effect towards inhibiting HCC proliferation, infiltration, metastasis and angiogenesis.
COBI possesses higher specificity towards inhibiting CYP3A4 35 and is also being used as a boosting agent for protease inhibitors atazanavir and darunavir.
The UIMn structure provides an obvious explanation for the pronounced selectivity of this class of small molecules towards inhibiting strand transfer (Espeseth et al, 2000).
Therapies directed towards inhibiting the induction of EMT may therefore reduce the formation of mesenchymal-like CSCs and improve clinical outcome.
Interest in applying carnobacterial bacteriocins in foods and feeds has been directed towards inhibiting Listeria monocytogenes (Table 3) and spoilage microorganisms, to extend the shelf-life of lightly preserved seafood (Einarsson & Lauzon, 1995).
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