In his iron will and tenacity, his 'never say die' attitude towards fate, his mystic faith in another world, he represented what is best in all of us".
Instead of identifying a mechanism of "ligand memory" capable of instructing T-helper fate, we conclude that Notch is not capable of inducing the initial steps towards fate acquisition.
For all its sensationalism, however, this is also a very moral film, with all its characters inexorably heading towards the fates they bring upon themselves - it's a brilliant portrait of the dog beneath the human skin.
Knowing how these multipotent cells are driven towards distinct fates could, in due course, allow patients to receive regenerative therapies for tissues lost to a variety of pathologies.
I've stepped back from the online cancer community for a while, and while I'll always support those who share this unfortunate bond with me, I'm letting go of the sense of ownership I feel towards their fates.
The resulting heterogeneous distributions of transcription factor concentrations will bias ICM cells towards specific fates (Xenopoulos et al., 2015).
This result supports the hypothesis that the first zygotic layer of the segmentation network directly canalizes cells towards normal fates.
One interpretation of this finding is that ESCs cultured in serum are strongly biased towards embryonic fates, and as a consequence have blocked the PrE-like differentiation program.
In wild type cells, their effects are almost indistinguishable, resulting in a bias towards prestalk fates, suggesting that RasD transcription is limiting.
It has been suggested that its tumor-promoting activity results from its involvement in restricting differentiation towards alternate fates and thereby allowing self-renewal and survival of relatively undifferentiated cells.
