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Non-profits tend to face some of the messiest, toughest problems society has to offer.
It has been one of the toughest problems in genetics.
I'll ask people how they solve their toughest problems.
On the toughest problems facing Argentina, the president largely remains mum.
One of the toughest problems for downtown businesses is trying to replace the customer base.
A KIND OF GENIUS: Herb Sturz and Society's Toughest Problems, by Sam Roberts.
Can charities really offer sustainable and scalable solutions to tackling the toughest problems in our country?
"We are the largest provider of technology in the world," she said, "We solve the toughest problems".
Charles Darwin considered the evolution of the human eye one of the toughest problems his theory had to explain.
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Dr. Back says that the Zoomar is unquestionably the toughest problem he ever tackled.
The toughest problem with small businesses isn't getting them started.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com