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Pharmacokinetic evaluation in a single patient during a hemodialysis session suggested efficient removal of both antibiotics, with total (unchanged and metabolites) SMX clearance increasing approximately 3.5-fold over non-dialysis periods (83.9 versus 24.4 ml/min) [23].
Approximately 50% of total (unchanged and metabolites) SMX and TMP body stores was removed by a four hour dialysis with a 1 m2 cuprophane dialysis membrane at a blood flow rate of 200 ml/min and dialysate flow rate of 500 ml/min [24].
Pharmacokinetic evaluation in a single patient during a hemodialysis session suggested efficient removal of both antibiotics, with total (unchanged and metabolites) SMX clearance increasing approximately 3.5-fold over non-dialysis periods (83.9 versus 24.4 ml/min) [ 23].
Approximately 50% of total (unchanged and metabolites) SMX and TMP body stores was removed by a four hour dialysis with a 1 m cuprophane dialysis membrane at a blood flow rate of 200 ml/min and dialysate flow rate of 500 ml/min [ 24].
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