Support types were categorized by number of paws on ground expressed as a percentage of the total stride duration for each stride.
We present only the normalized stance and propulsion data, since in all groups and for both legs the brake time and total stride time were not statistically different from pretreatment values.
For the mouse from the OA + HA group, the total stride time was also essentially constant at approximately 280 milliseconds throughout, and there were no marked changes in individual parameters from baseline at any time.
For this mouse (at all times), the percentage stance time (percentage of total stride time where stride time = stance time + swing time) was about 48% (composed of approximately 26% brake time and about 22% propulsion time), and the percentage swing time was 52%.
In the OA mouse, the total stride time (stance time + swing time = approximately 280 milliseconds) was not markedly changed over the course of the experiment; however, alterations in individual percentage stance time, propulsion and swing times were detected as early as day 5, and these data were increased further on days 12 and 19.
Walk with easy, full strides.
From these time slots in total 3118 walk strides and 9308 trot strides were selected after stride split.
The portion of excluded 〈 d i (t)〉 was less than 10% of the total number of strides for all participants and these strides were typically short periods of deviating patterns of the acceleration and velocity signals due to large deviations from normal patterns.
A total of 36,369 strides were collected from wildtype controls, which corresponds to 1069 ± 266 strides per mouse and 267 ± 66 strides per paw.
The individuals were projected, as supplementary observations, on the reference PCA plane that we previously defined in [ 3], using eight healthy and 11 GRMD adult dogs, and the seven following variables: stride length/HW, stride frequency, total power, medio-lateral, cranio-caudal, dorso-ventral parts of the total power, and regularity.
