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Comparison of renal clearance to total serum clearance suggests that between 25%and33%3% of drug clearance is renal.
The total serum clearance (CL) and the volume of distribution at steady state (Vss) were calculated by using the standard software formulae of CL = Dose/AUC0-∞ and Vss = CL*MRT (where the mean residence time was derived from the area under the first moment versus time curve).
A two-compartment model was used to calculate serum pharmacokinetic parameters of AUC (area under the serum concentration curve extrapolated to infinite time), CL (total serum clearance), T1/2α and T1/2β (half-lives of the initial and terminal phases of disposition) for I- and In-ch806.
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To assess systemic BA clearance during hypercholanemia, total serum BA concentrations were determined in time in these mice after gallbladder cannulation, without prior TCA administration.
The parameters assessed in the approach to IgA nephropathy were serum creatinine, creatinine clearance, serum albumin, total serum protein, 24 hours proteinuria, glycaemia, serum sodium, potassium, calcium and phosphorus ions, analysis of urinary sediment, serum complement profile, blood count, and renal biopsy.
Serum samples (20 μL) were measured for total serum bilirubin using a Bilirubinometer (B-105N, Erma, Tokyo, Japan).
Serum samples were immediately measured for total serum bilirubin (TSB) levels using a Unistat Bilirubinometer (Reichert, Inc.).
Total serum IgG concentrations were determined.
The duration of POP inhibition of compounds was evidently not governed by their serum clearance.
Serum clearance of I-124 codrituzumab is shown in Fig. 5.
Total serum gammaglobulins were measured by serum protein immunoelectrophoresis.
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