Sentence examples for total respiratory capacity from inspiring English sources

Although oxygen consumption in COLO-205 cells treated with HA is only ∼35% of control cells, maximal respiration rates in the presence of the uncoupler CCCP, are identical for treated and untreated cells, suggesting that the total respiratory capacity is maintained for a significant period, in agreement with the complex assembly data (Figure S2).

Together, these results indicate a mitochondrial dysfunction, where the MnSOD-kd cells leak protons and operate significantly closer to the total respiratory capacity.

This analysis demonstrated that the mutant MEFs show significant defects in basal respiration, oligomycin-sensitive respiration and total respiratory capacity (Fig. 4C; supplementary material Fig. S5).

While control HepG2-sc cells utilized only about 50% of the ETS's total respiratory capacity, MnSOD-depleted cells required about 65% for routine respiration.

In addition, proton leakage after inhibition of ATP synthase with oligomycin indicated an increased potential of superoxide production (19%) for MnSOD-kd cells compared to the 12% of total respiratory capacity observed for HepG2-sc cells.

Oligomycin (an ATPase and complex V inhibitor), carbonylcyanide- p-trifluoromethoxyphenylhydrazone (FCCP, a mitochondrial uncoupler) and rotenone plus antimycin A (inhibitors of complex I and complex III, respectively) were used in order to measure basal respiration, oligomycin-sensitive respiration (typically reflecting complex V activity) and total respiratory capacity, respectively (Fig. 4C).

This increase, in combination with the sRC, represents the "total reserve respiratory capacity" (tRRC) of the cell [47], [48].

An analysis of basal respiration rates and maximal induced respiration (in response to FCCP treatment) did not reveal a significant influence of Sod2 gene status on the respiratory capacity of total bone marrow cells of 8 to 11 month old mTerc + and G3 mTerc -/-mice (Suppl. Figure 2A).

Additionally, both the maximal respiratory rate and the spare respiratory capacity of Vector cells, defined as the total area under the curve (AUC) between the addition of cyanide p-trifluoromethoxy-phenylhydrazone (FCCP) and 2-deoxyglucose (2-DG) and the same AUC minus basal respiration, respectively, were also significantly attenuated in Drp1 cells.

These results accounted for the high variability in functional residual capacity (a hallmark of ARDS) and the ratio of lung elastance to total respiratory system elastance.

It has been described that lack of Psd1p leads to a substantial decrease of PtdEtn in total cellular and mitochondrial membranes, thereby conferring a petite phenotype, which is linked to the loss of respiratory capacity.