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or, after one or two years' improvement, suffer a partial or total recurrence of pain.
Two more patients had a recurrence at a different site, for a total recurrence rate of 20%.
Multivariate analysis showed that tumour invasion more than the serosa or lymph node metastasis are risk factors for total recurrence.
Items for assessing long-term outcomes included disease-free and overall survival rate at 5 year, total recurrence, hepatic recurrence, and extrahepatic recurrence.
Together with classic prognostic factors, the intrinsic subtype data provide information with which to appraise the total recurrence risk for a given patient.
In addition, the low number of total recurrence or death events should be acknowledged as a general limiting factor for data analyses.
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No differences between the two groups were found in overall survival, total recurrence-free survival, or local recurrence-free survival.
Our analysis identified only treated recurrences, which may be less than the number of total recurrences, so our estimate of disease-free survival may be overestimated.
Therefore, we can say that locoregional recurrence accounts for about one-third of total recurrences in some clinical series, but it is difficult to conclude that similar locoregional recurrence rates mean no need for adjuvant radiotherapy.
Similar to results reported for colon cancer [ 2], our study of BC has shown that regular intake of aspirin (at least 100 mg daily for a minimum of 2 years) significantly reduces the number of resections, number of patients with recurrence, total recurrences, and the number of lesions in recurrence compared to similar conditions in the entire population studied.
The total sample recurrence rate as well as recurrence rates that are specific to the 0.4 mg and 4 mg folic acid groups will also be compared to the recurrence rates of oral clefts in a historical control group.
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