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Exact(7)
Approximately 60 patients will be enrolled per institution, for a total recruitment of 300 patients.
Assuming a loss to follow-up of 10%to20%0%, a total recruitment of 33 subjects per group was necessary to ensure an adequate minimum sample size.
A total recruitment of 50 eyes was planned for the study, with an AcrySof® Toric IOL (Alcon, Fort Worth, TX), implanted in each eye that was enrolled.
This became obvious when we quantified the total recruitment of LC3B to all intracellular beads, regardless of whether they were positive or negative for p62.
Assuming a loss to follow-up of 10%to20%0%, a total recruitment of 51 subjects per group (total n = 153) was necessary to ensure adequate minimum sample size.
Based on these estimates a total recruitment of 450 women will enable detection of significant differences of clinical relevance for the primary outcome and for some key secondary outcomes.
Similar(53)
After 6 months of recruitment, initial rates of recruitment will be used to project total recruitment, to ensure sufficient participants to power the trial.
We have conservatively factored in a dropout rate of 15% giving a total recruitment required of 76 subjects (38 in each group).
Recruitment is still ongoing (start March 2013) with a total recruitment time of 8 months.
We enrolled our last participant on April 30, 2009 for a total recruitment period of 15 months.
Allowing for a lost-to-follow-up rate of 12%, 73 patients per group will be needed, to make a total recruitment target of 146.
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