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7. Total prevalence of diabetes & pre-diabetes.
This meant we could compare total prevalence trends including all diagnosed cases to corrected total prevalence trends.
The diagnosis of PH was later confirmed in 77 cases (89%); the total prevalence of PH was thus 19%.
About one third of the total prevalence is related to a diagnosis by a neuropsychiatrist during the observation period.
No decrease in total prevalence was found to have taken place during that period.
The diagnosis of PH was confirmed by the criteria described earlier in this text in 77 cases of the 87 (89%); the total prevalence is hence 19%.
Meanwhile, we recommend correcting total prevalence to 20 weeks GA instead of to LB, to avoid the assumption that late fetal loss for trisomies is constant across populations.
There was evidence of an increasing trend in the adjusted total prevalence of T13 and T18 (but not T21) over time, which may relate to improvements in diagnosis (prenatal and/or postnatal) over time; and evidence that France and Switzerland had higher T21 total prevalence than others, requiring further investigation.
Results: Total prevalence over the 1988–1998 period varied between 1.43 and 1.96 per 1000 live and still births.
We found evidence of some differences in total prevalence of the three trisomies over time and between countries that could not be completely explained by differing maternal age profiles or changes in GA at detection.
Weights representing the probability of fetal survival to 20 weeks GA were applied to each TOPFA case based on GA at TOPFA to correct for artefactual screening-related differences in total prevalence (Appendix).
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