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Consequently, the contribution of the kidneys to the total plasma clearance decreased during the study period.
The volume of distribution of cisatracurium is limited to the extracellular fluid (144 mL.kg-1), total plasma clearance is approximately 5.3 mL.min-1.kg-1, and the elimination half life is between 22 and 30 minutes [4, 5].
The terminal elimination half-life of CC is about (5 10 h) with total plasma clearance of 0.37 milliliter/min/ "ml/min/kg" and renal clearance of 0.19 ml/min/kg (Husain et al. 2011; Kolesar and Vermeulen 2016).
The total plasma clearance and apparent volume of distribution at steady state of tanshinol were 1.07 L/h/kg and 0.40 L/kg, respectively, whereas those of salvianolic acid B were 0.43 L/h/kg and 0.13 L/kg, respectively.
Total plasma clearance (CL) was calculated as Dose/AUC0 ∞.
The total plasma clearance (CL) of unbound platinum was calculated by Dose/AUC (ml min−1).
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The value of the total plasma iron clearance rate had to be prescribed as fixed value in order to avoid excessive parameter correlation (see paragraph "parameter identifiability").
Data by Trinder et al. [ 10] contribute an estimate of the total plasma turnover clearance rate (Additional file 1: Table S9).
At day 28, pharmacokinetics were slightly more than dose-proportional in the 200 mg bid and 400 mg qd groups (dose-normalized AUCs approximately 50% more than dose proportional with correspondingly lower total plasma oral clearance than seen with lower doses).
The starting infusion rate for cycle 1 did not allow for differences in renal function, as the total etoposide plasma clearance correlated only poorly with the EDTA creatinine clearance.
Total oral plasma clearance (CL/F) was described by the individual parameter estimates or population values [(when no PK data were available (n = 57)] obtained from a population PK model.
More suggestions(14)
total plasma radioactivity
total site clearance
total body clearance
total plasma bilirubin
total plasma peroxide
total creatinine clearance
total plasma concentration
total particle clearance
total network clearance
total plasma membrane
total stone clearance
total plasma exchange
total plasma homocysteine
total drug clearance
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