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Total phytoestrogen intake was computed based on legume consumption.
After adjusting for age, education, race, major reproductive risk factors, BMI and total calories, there was a suggestion of a decreased risk with phytoestrogen consumption, with an OR of 0.62 (95% CI: 0.38-1.00; p for trend: 0.04) for the highest tertile of total phytoestrogen intake from foods and supplements compared to the lowest.
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*Adjusted for age Age-adjusted means for phytoestrogen and total caloric intake in cases and controls are compared in Table 2. Total isoflavones, total lignans, and total phytoestrogen consumption, both from food only and from food and supplements, were lower in cases than controls, but none of the differences were statistically significant.
Total phytoestrogen consumption was computed by adding total isoflavones, total lignans and coumestrol.
It is premature to advise postmenopausal women with low phytoestrogen intake to change their diet towards a phytoestrogen rich diet with the sole aim to prevent cardiovascular disease.
No significant associations between pre-diagnosis phytoestrogen intake and factors associated with improved breast cancer prognosis were observed.
Conclusion: The results of this study suggest that an effect of dietary phytoestrogen intake at low levels on plasma lipid levels is of limited magnitude.
High/low phytoestrogen intake cut-off was the median level of intake in the control group.
However, a variation in risk by BMI and phytoestrogen intake was implicated.
Two aspects of the data on phytoestrogen intake should be noted.
The same method was used to assess the associations between BMI or dietary phytoestrogen intake and prostate cancer risk in strata of estrogen receptor genotypes, with adjustment for caloric intake in the analysis on phytoestrogen intake, age, and race.
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