No difference was observed between normal and hypothyroid PND7 pups in total pain intensity score with 0.3% solution of formalin.
With the exception of 2 subjects, in whom the referred pain continued in the absence of primary pain, the referred pain declined in parallel with local pain: the mean total pain intensity declined by 74% in both regions.
For assessment of pain intensity, questions 2, 3 and 4 of the CPG were used (see above) to yield a total pain intensity score (average of the 0-10 ratings of the 3 questions multiplied by 10 resulting in a 0-100 score) [ 36].
For estimating the burden of disease for headache means with 95%% confidence intervals (95 %-CIs) were calculated for each of the PedMIDAS questions, the PedMIDAS total score, the pain intensity and the number of headache days in the last three months.
Irrespective of how the burden of disease was classified (PedMIDAS total scale >30, pain intensity >5 or frequency of more than 6 days of headache in the last three months), use of health care appeared to be low in general.
The first three items rate pain, where the response format is 0= no pain and 10= worst imaginable pain, which is based on a calculation formula that gives a total score for pain intensity between 0 and 100.
Primary outcome measure was isometric knee-extension force (Steve Strong®), secondary outcome measures were health status (FIQ total score), current pain intensity (VAS), 6MWT, isometric elbow-flexion force, hand-grip force, health related quality of life, pain disability, pain acceptance, fear avoidance beliefs, and patient global impression of change (PGIC).
Construct validity was supported by the convergent validity in HIT-6 correlation with the MIDAS total score headache pain intensity, the number of HDPM and the negative correlations with SF-8 scales and summary scores, as well as by the discriminant validity across the different stages of headache.
These were converted into %maxTOTPAR or %maxSPID (the percentage of the maximum possible total pain relief or summed pain intensity), using verified equations [ 23- 26].
Pain intensity, total opioid dose, and postoperative time to first request for analgesic were evaluated.
In acute pain trials the outcome most often reported is total pain relief (TOTPAR) or summed pain intensity difference (SPID) over the four to six hours in which the studies are usually conducted.
