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This observed chemoprotective effect may be due to the sum total of interaction between different ingredients of this complex mixture.
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First, we generated 10,000 random matrices using the null model Patefield [35], in which the interaction frequency between two species is proportional to their total sum of interactions.
The total amount of interactions is 66 (combinations of eleven proteins taken by pairs).
In light of these changes, it is more appropriate that we re-imagine the sum total of interactions that determine health, including engagement, motivation, health behaviours, management and recovery, rather than simply re-imagining the role of the doctor in the curing of disease.
It is unlikely that the sum total of interactions inferred from the two-hybrid analysis occur in a single complex; rather, a small subset of these interactions may be in force at a given moment.
The relative contribution of each category to the total score of interaction counts/bin was calculated by dividing the category score through the total score of each bin.
Although Figure 3B schematically represents a parsimonious two signal model, the total number of interaction types could not be readily inferred through qualitative inspection of our dataset.
In table 5, the total effect of interaction confirms a synergistic effect.
The model also reveals parabolic relationships between the total number of interactions and the total number of interacting proteins.
– There is a parabolic relationship between the total number of interactions and the total number of interacting proteins.
The current analysis has revealed a total of 1,567 interaction hits whereas 1,392 (88.83%) of the total interactions are recorded in ABDA and 396 (25.27%) in DrugBank.
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