Additional file 6 lists the adjacency matrices for the motifs that are identified in conditional networks, total number of conditions they are present and the number of conditions they appear significant.
Presence or absence of each condition as well as total number of conditions was calculated.
The total number of conditions currently suffered was summed to create a continuous aggregate score of number of conditions.
There were no significant interactions between each of the main conditions and the total number of conditions.
Total number of conditions and some specific conditions predict OOPE but neither the clusters nor pairs of conditions were good predictors of OOPE.
This is particularly true for most GE matrices where the total number of genes largely exceeds the total number of conditions.
Total number of conditions and some specific conditions predict both OOPE and heavy financial burden but particular comorbid groupings are not useful in predicting OOPE.
Another parameter α determines the minimum number of samples for biclusters, given as a fraction of the total number of conditions, being its default value 0.05.
Second, the total number of conditions registered in the RNH database reflects the GPs perspective of the health status and relevant health problems of his patients.
Out of this information we calculated the mean total number of conditions and selected patient groups with the most frequently declared single comorbidities.
