There is good evidence that both acupuncture and acupressure are effective in postoperative nausea (total number of trials covered 24) while the results are equivocal for early morning sickness [ 40- 43] (total number of trials covered 8).
A total of 397 nausea rates were extracted for the remaining 150 medications that reported a numerical frequency.
This occurred in a total of 49 nausea rates associated with 45 otherwise eligible generic treatments, which were excluded from subsequent analyses.
The total duration of nausea or vomiting occurred over a median of approximately 2.5 days while on tigecycline therapy.
Therefore, the total sum of the nausea, vomiting, and retching experience points is defined as RINVR point.
Efficacy parameters included complete response (CR) (no emetic episodes and no use of rescue medication), complete control (CR with no more than mild nausea), and total response (CR with no nausea), and were summarized for the acute and delayed phases, for MEC and HEC.
For the FLIE assessment, significantly more NEPA-treated patients (79%) reported no impact on daily functioning for the total combined domains of nausea and vomiting during the 5 days after chemotherapy compared with those treated with oral palonosetron (72%; P = 0.005) [ 34].
The most commonly used conventional medicines against nausea in the total population were antihistamines, which were used by 613 respondents (6.7 %) (Table 2 and Additional file 2).
Total control of CINV (no nausea and no use of rescue medication) was achieved in 52.4% of patients in the former and 43.7% in the latter group (not statistically or clinically significantly different).
Of the 337 patients who received Infusion 2 at the faster rate, 22 patients (6.5%[955% CI, 4.1% to 9.7%]) experienced a total of 30 IRRs, with nausea (1.2%) and chills (0.9%) being the most common events.
Tests of the conditional likelihood ratio comparing item parameter estimates in different subpopulations defined by total scores on the EORTC nausea scale, by different time points and by values of exogenous covariates, revealed evidence against the Rasch models (c = 17.7, df = 8, p = 0.02).
