Sentence examples for total loss of function from inspiring English sources

Note that vps33 car is a hypomorphic allele with partial loss-of-function, while vps33 R281A is a functional null with total loss of function.

Under this system, athletes with total loss of function in their legs will compete together in most sports, because their functional loss is the same and the reason for the loss is immaterial.

In addition, his injury was reclassified as an incomplete spinal cord injury, meaning that he did not sustain a total loss of function below the damaged area.

Dysfunction of any component of this system will lead to variable degrees of compromise in the ability to perform motor acts, including total loss of function.

His injury was recently reclassified from a complete spinal-cord injury to an incomplete spinal-cord injury, meaning that LeGrand had not suffered a total loss of function below the damaged area, Rutgers said in a statement on its Web site.

The pathogenesis of human complex I deficiency to date has involved homozygous or complex heterozygous mutations resulting in near total loss of function in 10 human complex I subunits and 3 assembly factors [27].

It should be noted that we cannot fully exclude the possibility that the previous mutations were not total loss-of-function.

This phenotype strikingly resembles the unique total loss-of-function phenotype of Fgf10 mutants described by Min et al. and Sekine et al. [29], [30].

The insertion of a proline is likely to have a major impact on essential aspects of the protein structure of the FGF-domain and may cause a total loss-of-function.

The Dnmt1 n allele is an almost total loss-of-function mutation leading to severely reduced enzymatic activity of the protein (Li et al. 1992).

These ES cells were homozygous for the Dnmt1 c knockout allele, which results in a total loss-of-function (Lei et al. 1996).