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Based on the behavioral analysis mice shows decreased total locomotion, duration of immobility time and the locomotor counts.
Mice were placed in the center of the chamber and their behavior was recorded for 30 min. Quantitative analyses were performed on the following three dependent measures: total locomotion, locomotion in the center of the open field, and rearing rate in the center.
The total locomotion score (column 1) equals to the sum of columns a).
The cognitive test was conducted during the light phase of the day where no changes in total locomotion activity were observed between the two tested groups.
In contrast, locomotor activity and total locomotion in a new environment were increased in STI1−/+ mice (Fig. 3D,E; t(44)=1.879, P=0.0078).
In all cohort comparisons, behaviors related to movement (including total locomotion, dark cycle and light cycle locomotion, bout patterns of locomotion, and locomotor time budgets) were over represented.
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This system is an open-circuit instrument that determines: (1) the energy consumed by the amount of caloric intake (kilocalories) along time (hours) and normalized by the lean mass (kilograms); (2) the ration between the CO2 production and O2 consumption (VCO2/VO2); and (3) the total horizontal locomotion.
Post-hoc analysis revealed that total distance of locomotion in juvenile NHL rats (25.2±1.3 m, n = 25) was significantly higher than that in CTR rats (18.1±1.3 m, n = 22; P = 0.041 for NHL vs. CTR; Fig. 2a, b).
The total amount of locomotion did not vary across trials (F4,56 = 0.096, n.s).s
The data on entries into a new area were used to calculate the total amount of locomotion (number of entries into all areas summed together) and the percentage of entries that were in made into the central area.
Thus, the combination of FK565 or MDP plus 0.83 mg/kg LPS decreased novelty-related locomotion (total distance traveled) in the OF 21 h post-treatment compared to LPS.
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