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Total lifetime exposure was no better at predicting risk than daily frequency or duration of habits.
Most of these risk factors can be linked to total lifetime exposure to bioavailable estrogens.
High total lifetime exposure to estrogen correlates with an increased incidence of breast cancer.
Epidemiological studies indicate that total lifetime exposure to estrogen predict the risk of breast cancer [ 4, 5].
Total lifetime exposure to estrogen (E2) is the single greatest environmental risk factor for breast cancer (Dunn et al. 2005).
These results demonstrate the need to periodically test all drinking water tube wells so that the total lifetime exposure to As can be reduced.
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For these analyses, we estimated exposure with total lifetime exposure-days to carbofuran.
We calculated intensity-weighted exposure-days as the product of the intensity score and total lifetime exposure-days.
Although it is possible that better measures of total water intake could yield more refined exposure estimates that would reveal some misclassification of total lifetime CDBP exposure in our study, the lack of suggestive evidence for any impact on risk of adjustment for tap water intake makes it unlikely that our analysis is missing important risk effects.
When the deaths were classified by total lifetime arsenic exposure, the respiratory cancer mortality was linearly related to the amount of exposure.
Skin cancer risk is correlated with total lifetime sun exposure and frequency of sunburns.
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