A total of 44 dissemination nodules were detected in the NaCl group.
The total volume of dissemination nodules was significantly lower in DW-injected mice than in NaCl-injected mice.
The total number of dissemination nodules was significantly decreased by the DW treatment (NaCl group: 8.8 ± 1.4; DW group: 1.2 ± 0.8; mean ± standard error of the mean (SEM)).
The total weight of dissemination nodules was slightly less in the DW group (114.8 ± 67.2 mg) than in the NaCl group (423.2 ± 128.6 mg) (P = 0.059)).
The total volume of dissemination nodules was significantly lower in the DW group (123.8 ± 80.0 mm) than in the NaCl group (504.7 ± 150.2 mm)).
Our results showed that the total volume of dissemination nodules was significantly lower in DW-injected mice than in NaCl-injected mice.
The total number of dissemination nodules was 50% less with the peritoneal injection of DW than with that of NaCl (NaCl group: 10.3 ± 1.2; DW group: 5.0 ± 2.5; P = 0.081)).
In conclusion, ICGm selectively accumulated in tumor tissues as a result of the enhanced permeation and retention effect, and PDT using ICGm reduced the total amount of dissemination and improved the survival rate.
The total time for the dissemination of the alert would be less than 1 min.
Tree construction always increases the total required time for data dissemination and is not robust in high-node mobility and churning.
