Separate stepwise Cox multivariable proportional hazards regression models with total death, cardiac death and SCD as the dependent variable, and 25(OH D and other variables as potential independent predictors (listed below) were fitted.
However, in that study they included 1783 healthy middle-aged subjects of both gender with a follow-up of eleven years during which they identified 298 combined CHD cases, whereas we investigated total and cardiac death in chest pain patients with suspected ACS.
In the univariate analysis of continuous 25(OH D values in the total population, the HRs for total mortality and cardiac death were 0.99 (95% CI, 0.98 1.00), P = 0.035, and 0.99 (95% CI, 0.98 1.00), P = 0.060, respectively.
In the univariate analysis of continuous 25(OH D values in the female population, the HRs for total mortality and cardiac death were 0.98 (95% CI, 0.97 1.00), P = 0.023, and 0.98 (95% CI, 0.97 1.00), P = 0.044, respectively.
In the univariate analysis of the TnT positive population, the HRs for total mortality and cardiac death were 0.99 (95% CI, 0.99 1.00), P = 0.012, and 0.99 (95% CI, 0.98 1.00), P = 0.055, respectively.
The clinical endpoints followed up in the disease cohorts are (1) total mortality, (2) cardiac death, (3) cardiovascular death including fatal cardiovascular events such as cerebrovascular diseases, and (4) cardiovascular events including the combined endpoint of cardiovascular death and non-fatal myocardial infarction (Table 3).
QTc interval was not associated with total mortality, sudden cardiac death, or fatal CAD events over 30 years in the Framingham Heart Study (13) or with all-cause and CVD mortality over 9 years in a large Finnish population-based Health 2000 Study (12).
Thus, using survey results and the total number of sudden cardiac death events, we derived the expected number of sudden cardiac death events associated with each duty and calculated ratios of observed to expected (O E) events.
A significant reduction in risk of nonfatal myocardial infarction, sudden cardiac death, and total cardiac endpoints was observed in the intervention group.
In contrast to many other studies, we have focused not only on total mortality but also on cardiac death in our selected high risk population.
