Total body clearance was 0.12, 0.03 and 0.48 L/min kg for deoxynivalenol, T-2 toxin and zearalenone, respectively.
Total body clearance, volume of distribution at steady-state and half-life of denaverine are 5.7 ml/min per kg, 7.1 l/kg and 33.8 h, respectively.
Mean intravenous salicylate apparent volume of distribution was 0.2 ± 0.005 L/kg, total body clearance was 4.3 ± 0.2 mL/min·kg, and elimination half-life was 36.9 ± 1.2 min.
Engineering total body clearance or replacing the semiconductor core with a biocompatible and/or biodegradable nanomaterial prior to clinical translation may facilitate the eventual application of theranostic QDs in human patients.
Steady-state distribution volume (Vss) of (2.14±0.11) L kg−1 and total body clearance (CL) of (2.84±0.19) L h−1 kg−1 were determined for CYX after i.v. dosing.
The volume of distribution at steady state (Vdss) was 0.32 ± 0.01 l kg−1 and the total body clearance (Cltot) was 0.11 ± 0.01 l kg−1 h−1, respectively.
Total body clearance (TBC) correlated within each group linearly with K 1.
The median total body clearance of trimetrexate for each dose level was independent of dose but the total body clearance varied widely among patients at a given dose level.
These differences have been partially attributed to higher bioavailability in females and higher total body clearance in males [18 22].
The total body clearance normalized to 1.73 m2 body surface area was 130 ml/min for vessel dilator and 293 ml/min for LANP.
