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The total administration of 8a was 3 g/kg during 8 h.
For a 70 kg human, this concentration would lead to the total administration of 28 and 140 mg.
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Obtaining a better understanding of the total administration cost of CBHI and the relative costs of different administrative activities is essential to fully assess the financial sustainability of this approach and its potential contribution to achieving UHC in low-income settings.
The rate of cases which discontinued S-1 administration due to adverse reactions was low in arm A than in arm B and the cumulative rate of total administration days of S-1 by day 112 (6 months after starting administration) in arm A was higher (69.4%) than that in arm B (54.4%).
In addition, 15.6% of the total administration dose of teneligliptin was eliminated via hemodialysis.
Planned treatment was given in 40% of patients in arm A and 29% in arm B. The cumulative rates of the relative total administration dose of S-1 at 100% were 54.9%95%5% CI: 40.1 69.7%) in arm A and 34.3% (95% CI: 21.1 47.4%) in arm B, respectively (P=0.054).
The total administration days of S-1 (the planned total administration days of S-1, 112 days) was evaluated by the cumulative rate of patients.
Each subtest requires two to three minutes, for a total administration time of approximately 15 minutes.
The planned total administration days of S-1 was 112 days in both arms and the planned total administration doses of S-1 were also identical in both arms.
The mean of total administration days in each arm was almost identical (87.3 days vs 87.2 days) (Table 3).
Furthermore, the cumulative rate of relative total administration dose calculated by the rate between the actual total administration dose and planned total administration dose of S-1 was higher in arm A (54.9%) than arm B (34.3%).
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