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Hedlund was similarly committed to the cause, turning down other parts during the long and tortuous development period so that he could be available for the part of Dean Moriarty when the film finally got the green light.
Will there ever be a good moment to cite the notion of a responsibility to protect unanimously adopted by more than 150 states at the UN World Summit in 2005 as Mr Kouchner is now suggesting?The tortuous development of that concept is a tale close to the French minister's heart.
Initially, they designed a section called "10 years of tortuous development" on the 1950s and '60s, including the Great Leap Forward's devastating famine, according to Kirk Denton, a professor at Ohio State University who is writing a book on China's museums.
The tortuous development of "Behind the Candelabra" — and the way the studios all scurried from the material — surely contributed to his frustration.
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Most importantly, the first rational therapeutic agents targeted at oncogene products have now navigated the tortuous drug development pipeline.
In the high-fat diet groups for 8, 12 and 16 weeks, the portal vein became wider and tortuous during the development of hepatic disease when compared with the control group.
This gave rise to alumina film encroachment beneath the particles with development of tortuous porosity and, eventually, occlusion of partially anodized particle in the anodic film.
In the Experimental group, portal vein became wider and tortuous during hepatic disease development when compared to Control group.
These forces are not now in exact alignment at ground zero, although it is possible -- given the tortuous history of other major development projects in the city, like 42nd Street and Battery Park City -- to marvel at the fact that an official plan has been promulgated so quickly.
The apparent increase in ITA2B observed in oligoarticular patients may result from leaky and tortuous vessels observed in the development of synovitis.
Opposition to new developments and a tortuous planning process also put up costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com