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Furthermore, characteristic hypometabolic abnormalities were also evident in this mild cognitive impairment sample, demonstrating major topographical overlap with the connectivity disruptions.
The patterns of hypometabolism and regional cortical hub disruption in mild cognitive impairment showed striking similarity, with a topographical overlap of 42%, indicating that the two different functional abnormalities are distinctly regionally interrelated.
In all of the studies describing anatomofunctional subdivisions or zones within the STN we have reviewed, the respective authors carefully discuss the existence of topographical overlap between the subdivisions.
To quantitatively evaluate the topographical overlap between the patterns of whole-brain connectivity disruption and hypometabolism in mild cognitive impairment, we calculated a dice coefficient of similarity between the two findings (Zou et al., 2004).
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Convergence of multiple afferents on overlapping topographical targets provides strong evidence that neurons there comprise local circuits through which the SCN integrates and relays afferent signals reporting environmental or organismal change.
Haematoxylin-eosin preparations permit to have an overview of the histological structure of the tissue and to visually locate the topographical distribution of the substance, overlapping it with the IMS images.
For example, M1 topographical representations generated using transcranial magnetic stimulation (TMS) show greater overlap and a reduced number of discrete peaks in chronic low back 9 11 and elbow pain, 12 and these changes are associated with pain severity and/or motor dysfunction.
These studies provide evidence for a topographical organization within the STN, although it remains unclear to what extent functionally and anatomically distinct subdivisions overlap.
However, the interpretation of the topographical pattern of this study differs to ours, in proposing a concentric organisation for frequency representation overlapping with an angular representation of modulation rate in contrast to our interpretation of a concentric organisation for modulation rate and an angular representation of frequency in core areas.
A topographical organization within the STN may be present; however, it remains unclear to what extent functional and anatomical subdivisions/zones overlap.
We document significant overlapping between proximal and distal muscles, in line with many animal studies involving the superposition of topographical maps of the motor cortex obtained by microstimulation and morphological connectivity maps obtained by tracer injections.
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