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The topmost score for every protein pair is then chosen to capture the highest similarity an Mtb protein has in any of its pockets with any human protein.
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The topmost group regarding eigenvector score (above mean) comprises all researchers who formed the topmost group regarding in-degree analysis.
The final rescoring was done on the topmost poses from the grid score, using amber score (binding energy).
A systematic binding site comparison of this predicted pocket against a database of approved drug-binding sites yielded nilotinib (NIL) binding site from human mitogen activated protein kinase 11 protein (PDB ID: 3GP0) as the topmost hit with binding site similarity score (PMAX) (13) of 0.703.
For an experimenter, a judicious approach would be minimizing the number of CDKIs to be characterized by increasing the threshold to higher SVM score, in order to get only the topmost candidates for further work.
This contrasted with the ethylene biosynthesis pathway (ETHYL-PWY, Fig. 3b), which had a lower enrichment score (0.15) and fewer genes in the topmost ranks.
Finally, in the Annotation module, we did the following: Starting from an initial list that contains top-ranked k GOID, select GOID one by one down the list until the score difference of current GOID with the topmost GOID is above threshold h.
The topmost curve indicates the most likely response by participants in different score intervals.
The last researcher from the topmost group formed in the in-degree analysis has an eigenvector score between μ and μ + σ, together with two researchers who were part of the second group regarding in-degree analysis.
Our patient scored herself at +7, thus rating herself at the topmost level of improvement.
The topmost inhibited function was 'organismal death' (p-value 1.96E-03; 150 molecules; activation z-score -11.38).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com