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Interestingly, Fan et al. found that topical vaccination requires the presence of intact hair follicles, which are the most relevant physiological breaks in the skin barrier.
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Our previous study showed that even without topical Imiquimod vaccination with MelQbG10 induced increased percentages of CM-phenotype cells 10.
As such, the need is urgent for woman-controlled, safe, effective, and inexpensive topical microbicides, until prophylaxis through vaccination becomes globally available [2], [3].
Topical application or a single vaccination regimen might have less effects on pre-existing autoimmunity.
When's the last time any other scientific topic aside the age-old arguments about evolution and childhood vaccination passed through the barrier of topical interest and into the mainstream?
This confirmed earlier T cell chemo-vaccination reports in nonhuman primates receiving topical ARVs by others and us [13], [15].
Topical, huh?
Topical thriller?
Mmm, topical.
A gripping, topical adventure.
Mary Tyler Moore is topical.
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