Feared adverse effects of long-term, topical corticosteroid maintenance treatment are atrophy, striae formation, rebound reactions, fungal infections, reactivation of human papilloma virus (HPV) and herpes simplex virus infection, or systemic absorption.
Long-term follow-up in 83 women (with a median follow-up time of 4.7 years) confirmed a high rate of relapses of 84%% at 4 years [ 79], but even with long-term, ultrapotent, topical corticosteroid maintenance treatment, tolerance in this cohort was excellent.
In the patients with healed CAF, after standard conservative treatment with topical nitrates, the maintenance therapy with PHGG (5 g/die) for 10 months seems to significantly reduce the recurrence rate and significantly increase the success rate at 1-year followup.
Patients were on maintenance treatment with topical ganciclovir for an average of 9.1 ± 2.5 months for each episode of uveitis flare.
The fourth section had a variety of questions to determine perceived disadvantages of each treatment, as well as more detailed questions on the administration of methotrexate and what dose levels of systemic and topical corticosteroids are considered acceptable maintenance doses.
Therefore, a maintenance treatment with topical calcineurin inhibitors has been recommended.
To prevent recurrence of CMV endotheliitis and to preserve long-term corneal endothelial function, a maintenance therapy using topical anti-CMV agents needs to be developed.
Their maintenance treatment consisted of topical nasal steroid spray, nasal saline, montelukast, budesonide irrigations, and month-long bursts of oral steroids for exacerbations.
As work disability is also a major societal challenge, evidence about its preventable risk factors helps tackle the topical question of increasing labour market participation, and promotes maintenance of work ability.
Alternative local delivery of antibiotics by either topical administration or by a delivery device may enable the maintenance of a high local antibiotic concentration for an extended duration of release without exceeding systemic toxicity.
