The therapeutic potential of PXL150 in the treatment of topical infections was evaluated in an in vivo model of full thickness wounds infected with MRSA in rats and an ex vivo model of pig skin infected with S. aureus.
In specific, the cytotoxicity experiments show that the combinations have great potential in the treatment of topical infections.
Although Silver hopes the nanoparticles will be put to broad use, including for the treatment of topical infections, she sees even greater potential for the method her lab used to make them.
These are important factors as the issue of topical infections and bacterial resistance are by no means restricted to developed countries.
In a rat model of infected full thickness excision wounds, treatment by CEN1 HC significantly reduced the bacterial counts of MRSA as well as P. aeruginosa, the most common pathogens in topical infections in man.
We have previously demonstrated that one of two mineral products used to heal Buruli ulcer infections [16] has antibacterial activity against a broad-spectrum of pathogenic bacteria [17], suggesting the potential for therapeutic applications of minerals against topical infections.
In particular, MRSA and ESBL E. coli susceptibility to BY07 and CB07 highlights the potential for applications of hydrated mineral products or derivatives as complementary therapeutics in cases of antibiotic-resistant topical infections.
The antifungal activity exhibited by this compound warrants its use as an antifungal agent particularly for treating topical infections, as well as gargle mouthwash against oral Candida infections.
