In Le Tartuffe, and in Dom Juan (1665), topical references and satiric implications were so provocative in dealing with the delicate subject of religious belief that there were strong reactions from churchmen.
The implication for topical capsaicin-containing analgesics is that capsaicin can reside at the site of action (i.e. skin) relatively unchanged, whereas any capsaicin which is transdermally absorbed is rapidly eliminated.
She added, "The implication that a topical cream can do as much as a neurotoxin is wrong".
9 Experience in dermatology outpatient clinics has suggested that many patients are reluctant to use even mild topical corticosteroids, which may have important implications in terms of patient compliance and subsequent response to treatment.
The claim is topical, certainly, and it has profound policy implications.
The implications of natural licking in topical treatments are required to be seriously assessed to achieve optimal parasite control and to design parasitological and pharmacological studies within the drug approval process.
"And you're telling me that all those years of what being gay stood for is wrong?" As such lines suggest, much of what "The Normal Heart" explores is still at issue, including the very topical idea of same-sex marriage and its implications in redefining gay identity.
This is especially topical given the debate around various population-level proposals with public health implications such as alcohol unit pricing.
Our findings may have implications for the defense function of the stratum corneum and for topical gene delivery into the skin.
Despite the lack of positive findings in our population after correction for multiple testing, previous gene expression and association studies in schizophrenia suggest the implication of NgR signaling pathway genes in the etiology of schizophrenia remains topical and timely.
