Suggestions(1)
Exact(9)
For the IMQ-generated phenotype, the treatment protocol was to apply a daily topical dose of 62.5 mg IMQ cream (5% Aldara; 3M Pharmaceuticals) to the shaved back region of 8 10 week old C57BL/6 mice.
Interventions A single topical dose of chloramphenicol (n=488) or paraffin ointment (n=484; placebo).
In light of these results, we proceeded with a 0.5 mg/ml topical dose.
A single topical dose of EPO increased the median bone volume fraction.
Importantly, despite the high topical dose given, no hemorrhage was observed in the lung or at any surgical site.
However, the serum half-life time is short (six times shorter than in the vitreous) and the administered topical dose low.
Similar(51)
Systemic oxycodone exposure was insignificant after topical dosing.
Topical dosing of ophthalmic drugs to the eye is a widely accepted route of administration because of convenience, ease of use, and non-invasiveness.
A treatment designed using the release systems described in this study would represent a vast improvement over the current clinical standard of 56 84 topical doses over 28 days.
It has also been established that the release amounts of caffeine achieved after 8 h from the PA66 fabric are in the same order of magnitude than topical doses of commercial gel-based formulations.
To reduce possible long-term adverse effects, it is important to monitor its topical doses in daily clinics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com