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It follows that a topical microbicide that compromises this normally potent cervicovaginal barrier could substantially increase susceptibility to HIV or other pathogens.
Irreversible corneal decompensation has been described after topical administration of dorzolamide in patients with underlying corneal endothelial compromise.
Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin.
Unfortunately, patients chronically treated with topical glucocorticoids develop side effects, including cutaneous atrophy which affects all skin compartments and compromises the barrier function of the skin.
We can assume that people taking a regular dose of 5 mg of prednisolone (or equivalent) have compromised adrenal reserve; however, the degree of HPA axis suppression in persons taking inhaled, topical or intra-articular GCs is unknown.
In addition, damage to the local health care infrastructure can compromise the ability to properly irrigate contaminated wounds with sterile solution or promptly treat injured persons with topical or systemic antimicrobial drugs (32 ).
Topical, huh?
Topical thriller?
Mmm, topical.
So topical.
"Compromise, compromise, compromise," he said.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com