Exact(5)
These and other paradoxical discrepancies indicate a major contextual hazard associated with the topical component of SDD against which protocolized parenteral antibiotic partially mitigates.
Implications for research: "A logical next step for future trials would thus be the comparison of this protocol against a regimen of a systemic antibiotic agent only to see whether the topical component can be dropped.
Apart from major publication bias, or the effect of major and as yet unidentified and mal-distributed patient level risk factors for both VAP and bacteremia, these profound discrepancies indicate a major contextual hazard associated with the topical component of SDD on bacteremia within RCCT's against which protocolized parenteral antibiotic partially mitigates.
However, the protection appears marginal and non-significant among the remaining SDD-RCCT's for which either the intervention groups received only the topical component of SDD and not the PPAP component or among the SDD-RCCT's for which the control groups received the PPAP component (duplex studies) (Additional file 3: Figure S10).
Yet, if costs of the topical component of SDD and SOD would increase 40-fold to €400/day and €40/day (maximum values based on free market prices in 2012), the estimated ICER as compared with SC for SDD would be €21 590 per LYG.
Similar(55)
This is the case for the same topical components, such as Impact of minimum wage component, which was based on a WEF GCI survey question in 2001 and which became Hiring regulations and minimum wage of the WB DB after 2001, or for the Centralized collective wage bargaining component, which prior to 2002 reflected the Share of labour force whose wages set by centralized collective bargaining.
The picture is slightly more chaotic for the topical components of FGF signaling.
Furthermore, for SOD, but not for SDD, these findings were insensitive to current (higher) market-prices of the topical components.
SOD, but not SDD, was still dominant (ie, cheaper and more beneficial) over SC to current 40-fold higher market-prices of the topical components (€40/day for SOD and €400/day for SDD).
15 17 Antibiotic use consisted of the topical components of the SDD-regimen and SOD-regimen, hereafter referred to as study medication, and of all systemic antibiotics used in ICU during all periods, including the 4 days cefotaxime during SDD as part of the SDD-protocol.
The topical antibiotic component of SDD presents a major contextual hazard toward bacteremia against which the PPAP component partially mitigates.
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