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Oleic acid bound to cotton wound dressings may have promise in the selective lowering of cationic serine protease activity useful in topical application for chronic inflammatory pathogenesis.
PFS-based systems may be a promising platform for RP topical application for the treatment of skin aging.
The advantage of a topical application for 4 weeks is a continuous drug level during this critical phase.
reported no effect of glucocorticoids on mRNA expression of COL1A1 and MMP1 and on epidermal thickness after topical application for 7 days [ 33].
Therefore, we hypothesized that gallium salts used in a topical application for K. pneumoniae wound infections would also have efficacy with little or no toxicity because the compound was being applied directly to the site of infection, with limited exposure of noninfected organs.
In studies using the Phenion-FT skin model (Henkel KGaA), a marked decrease in collagen I synthesis and reduction in epidermal layers was observed by addition of glucocorticoids to the culture medium as well as by topical application for 11 14 days [ 28, 35].
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Our results contribute to understanding the mechanisms involved in surfactant toxicity, have a predictive value with regard to their safety, and may be used to design more effective and less harmful surfactants for use in topical applications for STI prophylaxis.
The need for woman-controlled, cheap, safe, effective, easy-to-use and easy-to-store topical applications for prophylaxis against sexually transmitted infections (STIs) makes surfactant-containing formulations an interesting option that requires a more fundamental knowledge concerning surfactant toxicology and structure-activity relationships.
Topical applications for percutaneous absorption comprise several forms, such as ointments, lotions, aerosols, liniments, cataplasms and plasters, and pressure-sensitive adhesives.
This plant has been used for centuries with both internal as well as topical applications for a wide variety of therapeutic properties which include antibacterial, antifungal, antioxidative, and antiviral activities.
10 In examining the role of topical applications for the sBCC it may therefore be necessary to define more clearly where surgery is inappropriate or not first line treatment so that the less invasive options such as topical applications can be recommended.
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