To enhance the local topical activity of HC, the terminal inactive metabolite of prednisolone, Δ1-cortienic acid (Δ1-CA), is added to HC, as Δ1-CA preferentially binds transcortin, liberating more HC to elicit its therapeutic effect.
Also, the topical activity of the NNRTI MIV-150 indicates promise for alternative strategies employing anti-viral drug-containing microbicide vaginal rings.
In addition, terconazole, possessing an alkyl group and triazole ring rather than the acyl and imidazole groups of ketoconazole, showed enhanced topical activity against superficial fungal infections.
Some of the commonly reported and minor adverse effects, such as hoarseness/dysphonia, are related to local topical activity, whereas adverse effects related to systemic exposure, such as adrenal suppression, although more serious, are very rarely reported [ 20].
Defensive chemicals in one species are often a mixture of chemicals and can be multifunctional by including chemical precursors, solvents, and/or wetting agents of the active compounds, by showing a feeding deterrence and toxicity, or a repellent and topical activity, etc. [ 4, 5, 15, 28- 31].
It is known that clearance of H. pylori from the stomach of infected patients can be due to the direct topical activity of the ingested drugs at the gastric mucosal epithelium, and specially the secondary systemic therapeutic activity, which result from the back secretion and re-entry of the absorbed active principle from the basal to the apical side of the gastric epithelium.
A series of novel FP prostaglandin analogs was designed to optimize topical ocular activity and reduce ocular side-effects by replacing 13-carbon with oxygen.
These cases provide early evidence that the use of the BED is feasible in a small animal clinic and may support healing while providing topical, nonantibiotic activity against wound pathogens.
Although E. foetidum leaves have been previously reported to exhibit topical anti-inflammatory activity, anti-inflammatory activity as an actual consumption has not been reported.
Furthermore, was observed an appreciable and sustained in vivo topical anti-inflammatory activity of esters 1d and 3e, compared to the parent drugs, using MN-induced erythema in human volunteers as inflammation model.
Furthermore we investigated the in vivo topical anti-inflammatory activity of esters 1d, 2e and 3e, which showed the best in vitro profile, evaluating the ability of these compounds to inhibit methyl nicotinate (MN -induced skin erytheMN -inducedhy human volunteerskin
