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Authors' response: We highly appreciate these comments, which are rich in information potentially relevant to the topic of the manuscript.
We excluded 87 phrases (76 of which were spoken) that were coded as describing the title or topic of the manuscript, leaving 2376 coded phrases for analysis.
While all reviewers found the topic of the manuscript fascinating, several of them felt that further experiments were needed to clarify the model proposed.
The schematic Figure 7 shows the initial phase of the infection process (clearly the main topic of the manuscript), but it still does not address the final stage of the symbiosis.
While all three reviewers found your work to be technically sound and the topic of the manuscript to be very interesting, they were split in their views on whether the manuscript reported discoveries that were of sufficient novelty or significance to merit publication in a general readership journal like eLife.
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The topic of this manuscript is the evaluation of the function and importance of mtRF1.
MB, FC, GB and FZ were involved in revising results and in preparation of the different topics of the manuscript (surgery, radiotherapy, chemotherapy and infusional technique).
AO, CP, FC, FZ, were involved in revising results and in preparing the different topics of the manuscript (surgery, radiotherapy, chemotherapy and infusional technique).
NA, DE, DB, and RP are employees of, and YC is a consultant for AvanSci Bio, LLC that currently markets the mesodissection system, the topic of this manuscript.
Since this is not the topic of this manuscript, we concentrate our answers on the reservoir of infection (i.e., transmission, not necessarily incidence of malaria).
Remove the sentences beginning with "All batoids were identified... .......... through the end of the paragraph as this is not relevant to the topic of this manuscript.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com