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Whereas some evidence has been generated for a link between ECM‐induced alterations in tissue architecture and changes in both nuclear and chromatin organization, the manner by which these changes actively induce or repress gene expression in normal and malignant cells is a topic in need of further attention.
Not one singular topic in need of information prevailed.
We arrived at a rough, upper-bound estimate of 25% probability of honest reporting for the 2009 influenza A/H1N1p pandemic (see 'Materials and methods'), but we emphasize that this is a topic in need of further study.
Overall, these data suggest that mitochondria have a crucial role in the physiological balance between pluripotency and differentiation and, importantly, they allow us to discuss on the aging biology of iPSCs, which is a poorly understood topic in need of research attention.
Note, however, that the simulations are performed ignoring positive and negative selection, and the accuracy of existing methods to infer demographic parameters relative to one another in the presence of both positive and negative selection, and the impact of differing assumptions made in different approaches, remains a topic in need of more thorough investigation.
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Although our list is by no means exhaustive, it offers examples of topics in need of further work and directions that appear promising.
Data analysis methods are outlined for each of the study designs mentioned, with an emphasis on topics in need of further research.
Athlete's perceptions and belief systems surrounding weight cycling, social support, and injury reporting are all topics in need of further investigation.
Primary care practitioners identified a range of topics in need of further information including diagnosis, reducing the burden on primary care, and effectiveness of treatments.
Richard Owen's role in the formation of some of Darwin's thinking is a topic still in need of deeper exploration.
One final topic standing in need of treatment is contextualism about knowledge attributions, according to which the word 'knows' and its cognates are context-sensitive.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com