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This complicates the simple linear "top-down" concept of signaling pathways.
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Through the assessment, system level safety requirements can be allocated to subsystem and item level, which is the core part for implementing the top-down design concept.
A combination of top-down (project concept and technical design) and bottom-up (field implementation design) approaches was used at the macro and operative levels, respectively.
They are the elements of our top-down approach: starting from concepts to experiments.
The concept is top-down but preaches piecemeal, bottom-up development and reuse.
The concept of top-down stepwise refinement is covered and illustrated with a case study.
First of all, for both labels, the signifier (S) was introduced in a top-down manner, well before the concept that was signified by it (s) had acquired a clear and stable profile.
Instead, Zsyntax proposes a top-down approach based on the concept of drawing out the logic implicit in molecular biology (both theoretically and experimentally) and, as an inevitable consequence, it allows also to deal with biological networks.
Neo-reductionists also maintain that the concept of top-down causation is a mirage.
The participatory development methods allowed us to explore this novel concept matching top-down (expert-based views, medical protocols) and bottom-up (nurses' information needs) perspectives in a complex information context.
As a result, a larger computational burden is likely placed on hierarchical cortico-cortical networks while processing abstract concepts, as top-down and bottom-up circuits work to interpret contextual variability.
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CEO of Professional Science Editing for Scientists @ prosciediting.com