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He got everyone's attention and seems to have kept it by the way we're playing, and hopefully we can continue on and push for the top six, which was our target from the start of the season". Johnston left Rugby Park on 6 February, having revealed his intention to step down at the end of the season the previous day.
"Belgium will be favourites – we don't mind that because they have some top-quality players – but our target is to win the game.
"But a top-eight place is our target and these two wins keep us in the frame.
Our target is top four". A dominant second-half display from a fluent Liverpool.
We have got some very tough games coming up, but we're well in the mix for top four - that was obviously our target at the start of the season and it still is now.
"We have achieved our top four target and we know there is a semi-final coming, now we've got to dictate where it's going to be and that's very much in our hands.
However, we also identified KEAP1 as one of our top 21 BRD4 target genes.
Integration of both gene lists – the data obtained by the RNA-Seq and ChIP-Seq experiments – resulted in 52 commonly activated genes of BRD4, now considered as our top candidate target genes (Supplementary Table S3).
Our top de-regulated target TGFB1, which is a cytokine important for proliferation and differentiation of immune cells, was reported to be a marker for malignant transformation and drug sensitivity in melanoma cells [44].
By means of IPA, our top molecular targets for the Class A group were analyzed in a comprehensive way and thus pertinent canonical pathways and functional networks accounting for an invasion radiophenotype were uncovered.
As previous studies demonstrated that many known pigment regulators (KPRs) were not present in our top tier targets but did have some impacts on pigment production [ 13], we define SPRs as genes whose siRNAs have some impact on pigment production (Z-score < -1 or >1) (Additional File 2 Table S1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com