Exact(9)
To identify independent effects, we performed a forward stepwise logistic regression where the top marker, ranked by the log-likelihood P value, was included as a covariate by addition to the null model.
Interestingly, their top marker rs1183201 in the SLC17A1 gene did not show significant association with the qualitative trait of gout in our study.
The novel association of the oncogenic pathway activation status with a phenotype "captured" by a marker 19-gene profile, of which none of the pathway genes is a member, demonstrates that biological inference in microarray studies should not be limited to the frequently applied approach of screening a list of top marker genes in a prognostic signature.
QTLs location is given in cM from the top marker of the linkage group.
The single marker regression was also done fixing the top marker (higher F statistic) for each trait.
The fixation of the top marker for each trait still allows the significance of other SNPs to be detected.
Similar(51)
I let my hair down and put on bright lipstick and a V-neck top, markers of authoritative attractiveness meant to be seen from a distance, pathetic signals that I knew from chill, that my threshold for fun was high.
Similar observations were made on all the predicted top markers across the seven cancer types.
We further tested our top markers in 751 independent cases and 751 matched controls.
The ranking and threshold calculation was done separately for each of the top markers and showed that each marker has a different distribution of r2 across the genome.
The top markers as sorted for significance by the randomForest program were combined with various combinations of clinical variables using logistic regression R program (glm with family = binary (a logistic model), where glm refers to generalized linear model).
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