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Top down search algorithms have capitalized on this by allowing expanded precursor mass tolerances that can accommodate unforeseen PTMs and mass shifts (including subtractive modifications like sequence truncations or incorrect start sites).
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Its top-down search strategy is based on Mahanti and Bagchi's CF [J. ACM 32 (1985) 28], whereas its bottom-up revision process is inspired in Chakrabarti's REV∗ [Artificial Intelligence 65 (1994) 329].
They introduced some theoretical properties of refinement operators and used a downward refinement operator to enable a top-down search.
In [10], a top-down search algorithm was combined with a data-driven selection of candidates for DTW alignment to reduce search space, together with a flexible subword unit selection mechanism and a class-sensitive distance measure.
For our overt simulations we also show the effect of applying a "top-down" search strategy where a small leftward saccade is made to shift fixation back into the scene in the situation where fixation lands at the rightmost border of the scene.
It is important to disentangle such effects of perceptual difficulty from similarity, because arguably, they reflect impacts of different kinds of processes: Whereas differences in perceptual difficulty could modulate dwell times in a purely bottom-up, stimulus-driven manner, discovering an effect of target similarity would show an effect of top-down search strategies on dwell times [11].
To further characterize proteins in this category, we applied the Byonic top-down search to our data.
At present, NeuCode SILAC-labeled intact protein spectra are incompatible with existing top-down search algorithms, complicating data analysis.
The top-down search procedure (forced-choices) for the TTO method resulted in 95 subjects (70%) who were willing to trade some of their remaining life years in return for perfect vision.
The top-down search procedure (forced-choices) for the SG method resulted in 49 subjects (37%) who accepted death risk, 86 subjects (63%) did not accept any death risk.
In addition, they provide clues about what is required for efficient top-down visual search and the functional dissociation between perceptual representations and the process of attentional selection during visual search.
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