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In this way, the challenge of accurate gene annotation can be approached both from the bottom up (gene orthology) and top down (relationship to physiological functions), tying together microbial phylogeny and physiology.
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Where the conventional notion of the "worship leader" suggests a top-down relationship from pulpit to congregation, curated worship is conceived to open up space for participants to make the church experience their own.
Instead of a top-down relationship, we meet as equals.
When people talk about parenthood in the ballroom scene, a lot of emphasis is placed on the top-down relationship between parents and children.
"Bear in mind that China-DPRK ties should not be understood as a top-down relationship where the latter follows every bit of advice offered by the former," Xinhua said, referring to North Korea by its official name, the Democratic People's Republic of Korea.
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A "parametric" or "top down" estimate uses validated relationships among cost, schedule, and measurable attributes of systems, hardware, and software.
In Top Down, Karen Ferguson explores the consequences of this counterintuitive and unequal relationship between the liberal establishment and black activists and their ideas.
Harvard's administration was strictly "top down".
Top Down, Bottom UP.
Top down, pushing buttons".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com